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. 2019 Apr 12;62(11):5298–5311. doi: 10.1021/acs.jmedchem.9b00058

Scheme 2. Synthesis of Compounds 916.

Scheme 2

Reagents and conditions: (a) 1-butanol, R3-amiine, 120 °C; (b) R6-boronic acid, DME/water, Na2CO3, tetrakis(triphenylphosphine)palladium(0), 110 °C .