Table 3. Pharmacokinetic Parameters of Compound 11 in Rat^a.

dose (route)	male	female
2 mg/kg (iv)	T1/2 (h): 2.07 ± 0.313	T1/2 (h): 3.73 ± 0.288
	CL (L h–1 kg–1): 1.46 ± 0.236	CL (L h–1 kg–1): 0.677 ± 0.099
	Vss (L/kg): 3.57 ± 0.424	Vss (L/kg): 3.02 ± 0.372
2 mg/kg (po)	T1/2 (h): 3.13 ± 2.25	T1/2 (h): 4.71 ± 0.543
	Cmax (ng/mL): 222 ± 69.6	Cmax (ng/mL): 363 ± 116
	AUC∞ (h·ng/mL): 739 ± 84.8	AUC∞ (h·ng/mL): 2035 ± 193
oral bioavailability	53.0% ± 6.09	67.8% ± 6.43
6 mg/kg (po)	T1/2 (h): 2.87 ± 0.504	T1/2 (h): 5.07 ± 0.244
	Cmax (ng/mL): 392 ± 216	Cmax (ng/mL): 646 ± 98.7
	AUC∞ (h·ng/mL): 2601 ± 965	AUC∞ (h·ng/mL): 6632 ± 949
10 mg/kg (iv)	T1/2 (h): 2.38 ± 0.210	T1/2 (h): 3.73 ± 0.676
	CL (L h–1 kg–1): 1.71 ± 0.0512	CL (L h–1 kg–1): 0.816 ± 0.206
	Vss (L/kg): 4.63 ± 0.365	Vss (L/kg): 3.76 ± 1.19
10 mg/kg (po)	T1/2 (h): 3.47 ± 1.26	T1/2 (h): 4.45 ± 0.383
	Cmax (ng/mL): 649 ± 180	Cmax (ng/mL): 1203 ± 72.3
	AUC∞ (h·ng/mL): 3841 ± 152	AUC∞ (h·ng/mL): 10615 ± 738
oral bioavailability	55.1% ± 2.18	70.7% ± 4.92

^aValues are the mean ± SD.