Table 2.

Male physiology and echocardiography

	F1		ET		F2		F3		PF2
Parameter	Con	HFS	Con	HFS	Con	HFS	Con	HFS	Con	HFS
LV mass, mg	76.6 ± 0.9	80.2 ± 1.5*	88.8 ± 1.9	98.4 ± 4.1*	77.6 ± 1.4	82.8 ± 1.8*	75.1 ± 1.8	83.0 ± 2.6*	76.3 ± 1.8	83.6 ± 1.2*
Body wt, g	23.3 ± 0.2	22.7 ± 0.32	26.5 ± 0.4	25.8 ± 0.5	23.2 ± 0.3	22.4 ± 0.3	21.3 ± 0.5	22.7 ± 0.5	22.1 ± 0.4	23.4 ± 0.3*
LV mass/body mass, mg/g	3.39 ± 0.03	3.63 ± 0.03*	3.40 ± 0.04	3.70 ± 0.06*	3.37 ± 0.07	3.74 ± 0.03*	3.44 ± 0.15	3.57 ± 0.19*	3.28 ± 0.04	3.53 ± 0.05*
Tibia length mm	17.0 ± 0.1	16.5 ± 0.2*	17.5 ± 0.1	17.1 ± 0.1*	16.5 ± 0.1	17.0 ± 0.1*	16.8 ± 0.1	17.2 ± 0.1*	16.8 ± 0.1	17.4 ± 0.1*
LV Mass/tibia length, mg/mm	4.49 ± 0.06	4.97 ± 0.13*	4.84 ± 0.09	5.75 ± 0.23*	4.51 ± 0.08	4.86 ± 0.09*	4.35 ± 0.09	4.92 ± 0.17*	4.22 ± 0.10	4.84 ± 0.05*
LV internal diameter (diastole), mm	3.87 ± 0.10	3.39 ± 0.11*	3.35 ± 0.05	3.55 ± 0.08*	3.38 ± 0.07	3.52 ± 0.02*	3.51 ± 0.24	3.54 ± 0.12	3.45 ± 0.08	3.06 ± 0.06*
LV internal diameter (systole), mm	1.93 ± 0.04	1.60 ± 0.04*	1.60 ± 0.02	1.80 ± 0.07*	1.60 ± 0.05	1.78 ± 0.01*	1.63 ± 0.10	1.60 ± 0.05	1.65 ± 0.07	1.47 ± 0.04*
Relative wall thickness	0.44 ± 0.01	0.56 ± 0.06*	0.52 ± 0.01	0.46 ± 0.01*	0.55 ± 0.01	0.50 ± 0.01*	0.53 ± 0.06	0.46 ± 0.02	0.50 ± 0.02	0.62 ± 0.02*
Heart rate, beats/min	617 ± 8	621 ± 9	638 ± 15	627 ± 18	624 ± 8	626 ± 14	611 ± 13	592 ± 7	590 ± 12	602 ± 4
Fractional shortening, %	50.2 ± 0.1	51.2 ± 0.9	50.8 ± 0.4	51.8 ± 1.2	53.0 ± 0.8	49.5 ± 0.4	53.5 ± 1.2	54.7 ± 0.5	52.3 ± 1.1	53.1 ± 1.4
Myocardial performance index	0.49 ± 0.06	0.48 ± 0.03	0.40 ± 0.04	0.54 ± 0.04*	0.53 ± 0.04	0.55 ± 0.05	0.55 ± 0.03	0.53 ± 0.02	0.46 ± 0.02	0.59 ± 0.03*

Values are means ± SE; n = 20/group for body weight, LV weight, and tibia length; n = 5/group for echocardiographs except, and n = 7 for F2 males and n = 4 for PF2 mice.

^*P < 0.05 by Student’s t-test between Con and HFS groups within sex and generation.