Fig. 1.

Glucose and fatty acid metabolism in ex vivo isolated perfused hearts with cardiomyocyte-restricted deletion of stromal interaction molecule 1 (^crSTIM1-KO hearts). Ex vivo isolated working heart perfusion experiments performed on hearts from control and ^crSTIM1-KO mice. A−D: mean measurements of glucose oxidation (A), net lactate release (B), total glycolysis (glucose oxidation and net lactate release combined; C), and oleate oxidation (D). n = 3–4 mice/genotype. *P < 0.05 versus age-matched control mice (Student’s t-test).