TABLE VI.

Reports of death among reports of anaphylaxis

Patient no.	Age (y)	Sex	Past medical history	Vaccine(s) received	Time to onset (min)	Symptoms	Brighton level	Documented cause of death
1	2	Male	Born premature at 33 weeks’ gestation; hypoplastic left heart syndrome with subsequent cavopulmonary shunt procedure; periodic cyanosis	Inactivated influenza (not specified), combined measles-mumps-rubella, varicella vaccines	20	Received vaccinations and later experienced cardiopulmonary arrest. Postmortem laboratory tests revealed an increased serum tryptase level.	2	Anaphylactic reaction
2	42	Female	Asthma; hereditary onycho-osteodysplasia; allergies to penicillin, quinolones, and naproxen; hepatitis C infection	Inactivated influenza vaccine, trivalent	2	Received vaccine and intramuscular ceftriaxone concomitantly. The patient then experienced respiratory failure and died. Laboratory tests later revealed an increased serum tryptase level.	2	Anaphylactic reaction
3	43	Female	No hypersensitivities; hypertension; depression	Inactivated influenza vaccine, quadrivalent	<1 d	Received vaccine and was found dead the following morning. On autopsy, the body was noted to have patches of urticaria and airway swelling. Laboratory results included an increased serum tryptase level.	1	Anaphylactic reaction
4	46	Male	Asthma; unspecified allergies; chronic headaches; gout; hypertension	Inactivated influenza vaccine, trivalent	NA	Received vaccine and then had wheezing with subsequent cardiopulmonary arrest.	2	Acute asthmatic bronchitis
5	50	Male	Allergies to angiotensin-converting enzyme inhibitors; past anaphylaxis; hypertension; renal cell carcinoma	Pneumococcal polysaccharide vaccine	0	Received the vaccine and immediately had respiratory difficulty, seizure, and cardiorespiratory arrest.	2	Anaphylactic shock
6	65	Male	None	Inactivated influenza vaccine, trivalent	15	Received vaccine and then experienced airway swelling and cardiopulmonary arrest.	2	Anaphylactic shock
7	70	Male	No hypersensitivities; chronic obstructive pulmonary disease; coronary artery disease	Inactivated influenza vaccine, trivalent	258	Received vaccine and experienced difficulty breathing and then cardiopulmonary arrest.	2	Anaphylactic reaction
8	84	Female	Allergies to penicillin; hypertension	Inactivated influenza vaccine, trivalent	2	Received vaccine, “felt funny,” and then collapsed. The patient had ventricular fibrillation (later speculated because of hypotension), which progressed to cardiac arrest; on examination, she also had wheezing.	2	Not documented but medical records indicate diagnosis of anaphylactic reaction

NA, Not applicable.