Table 3.

Endogenous and synthetic inhibitors of ADAMs and ADAMTS.

Inhibitor	Target	Reference
Endogenous: TIMP-1	ADAM-10, 17	[194]
TIMP-2	ADAM-17, 33	[195]
	ADAMTS-1
TIMP-3	ADAM-10, 12, 17, 28, 33	[41, 55, 194,
	ADAMTS-1, 2, 4, 5	196]
TIMP-4	ADAM-17, 28, 33	[197]
α−2 macroglobulin	ADAMTS-2, 4, 5	[41, 55, 198]
Papilin	ADAMTS-2	[60]
Synthetic: Batimastat (BB-94)	ADAM-17, MMPs	[197]
Calcium pentosan polysulfate	ADAMTS-7, 12	[199]
CGS27023	ADAM-9	[200]
Cis-1(S)2(R)-amino-2-indanol-based compounds	ADAMTS-4, 5	[201]
GI254023	ADAM-10	[16]
GI254023X	ADAM-10, MMP9	[16]
Granulin-epithelin precursor	ADAMTS-7, 12	[172]
GW280264	ADAM-10, 17	[16]
INCB3619	ADAM-8, 9, 10, 17, 33	[16]
KP457	ADAM-10, ADAM 17	[16]
TAPI-1	ADAM-17/TACE	[202]
TAPI-2	TACE, ADAMs, MMPs	[202]