2. Optimal information size calculations; continuous outcomes.

Outcome	Type of test	Mean in control groupa	Mean in Intervention groupb	SD of outcome	Total sample sizec,d
Coma resolution time	Superiority	25	19	20	350
	Equivalence	25	19 to 31	20	382
Parasite clearance time	Superiority	42	36	20	350
	Equivalence	42	36 to 48	20	382
Fever clearance time	Superiority	48	42	20	350
	Equivalence	48	36 to 54	20	382

^aThe mean in the control group is taken from the median control group across studies.
 ^bA six‐hour time difference was chosen to represent a clinically important benefit.
 ^cThese calculations were performed using a power calculator available at: www.sealedenvelope.com/power
 ^dAll calculation were performed for a power of 80% and an α error of 0.05.