4. Characteristics of trials comparing artemether and quinine in adults.

Trial ID	Year of study	Age limits	Quinine dosing schedule			Artemether dosing schedule
			Loading dose	Maintainance	Follow‐on therapy	Loading dose	Maintainance	Follow‐on therapy
Hien 1996	1996	15 to 79 years	20 mg/kg IM	10 mg/kg IM every 8 hours	Quinine or mefloquine to complete 7 days	4 mg/kg IM	2 mg/kg IM once daily for 4 days	Quinine or mefloquine to complete 7 days
Karbwang 1992	1991	15 to 45 years	20 mg/kg IV	10 mg/kg every 8 hours for 7 days	Quinine to complete 7 days	160 mg IM	80 mg IM once daily for 6 days	None
Karbwang 1995	1994	15 to 55 years	20 mg/kg IV	10 mg/kg every 8 hours for 7 days	Quinine to complete 7 days	160 mg IM	80 mg IM once daily for 6 days	None
Seaton 1998	1995	> 12 years	20 mg/kg IV	10 mg/kg IV every 8 hours	Quinine to complete 7 days	3.2 mg/kg IM	1.6 mg/kg IM once daily for 4 days	None

Abbreviations: IM = intramuscular; IV = intravenous.