5. Characteristics of studies comparing artemether and artesunate in adults.

Trial ID	Year of study	Age limits	Artemether dosing schedule			Artesunate dosing schedule
			Loading dose	Maintainance	Follow‐on therapy	Loading dose	Maintainance	Follow‐on therapy
Phu 2010	2003	15 to 77 years	3.2 mg/kg IM	1.6 mg/kg IM daily	None	2.4 mg/kg IM	1.2 mg/kg IM once daily	2 mg/kg of artesunate to complete 7 days
Vinh 1997	1994	15 to 66 years	200 mg IM	100 mg IM once daily for 3 days	Mefloquine once	120 mg IM or IV	60 mg IM or IV once daily for 3 days	Mefloquine once

Abbreviations: IM = intramuscular; IV = intravenous.