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. 2019 Jun 17;19:131. doi: 10.1186/s12886-019-1136-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Instillation adherence. Patients in both groups were asked to instill drops 6 times per day: 2 times with cyclosporine plus 4 times with hyaluronic acid in the 0.05% cyclosporine group (CN), and 6 times with diquafosol in the 3% diquafosol group (DQ). All patients in both groups were allowed to instill hyaluronic acid ad libitum when they felt discomfort and they were told the total daily number of instillations should not exceed six per day as possible