Table 3.
Changes of TBUT values between CN and DQ group
| 0 | 4 weeks | 12 weeks | Difference (0–4 weeks)a | Difference (0–12 weeks)a | P value (0–12 weeks)b | |
|---|---|---|---|---|---|---|
| CN | 3.87 ± 1.32 (1.05~8.67) | 4.64 ± 2.10 (1.01~13.17) | 5.56 ± 2.50 (1.45~13.09) | 0.77 ± 1.78 (−2.29~6.64) | 1.69 ± 2.45 (−3.13~10.05) | < 0.0001 |
| DQ | 4.29 ± 1.85 (0.50~8.42) | 4.46 ± 1.66 (0.73~8.67) | 5.02 ± 1.85 (2.27~9.74) | 0.17 ± 1.95 (−4.96~3.27) | 0.73 ± 2.43 (−5.51~6.64) | 0.0281 |
| P value | 0.3459 | 0.7668 | 0.3033 | 0.7350 | 0.1521 |
CN 0.05% cyclosporin nanoemusion (0.5 mg/mL), DQ 3% diquafosol sodium (30 mg/mL)
aComparison between CN and DQ groups by Wilcoxon rank sum test
bComparison among three groups by Kruskal-Wallis test