Table 4.
Changes of Schirmer values between CN and DQ group
| 0 | 4 weeks | 12 weeks | Difference (0–4 weeks)a | Difference (0–12 weeks)a | P value (0–12 weeks)b | |
|---|---|---|---|---|---|---|
| CN | 8.67 ± 6.30 (2.00~35.00) | 9.50 ± 6.21 (0.00~30.00) | 10.14 ± 6.13 (0.00~30.00) | 0.83 ± 5.26 (−17.00~14.00) | 1.47 ± 6.20 (−20.00~19.00) | 0.0031 |
| DQ | 7.96 ± 5.55 (1.00~30.00) | 9.52 ± 6.71 (0.00~30.00) | 9.02 ± 5.59 (0.00~35.00) | 1.56 ± 5.45 (−14.00~20.00) | 1.06 ± 6.32 (−16.00~15.00) | 0.0643 |
| P value | 0.3955 | 0.9754 | 0.3675 | 0.9214 | 0.8597 |
CN 0.05% cyclosporin nanoemusion (0.5 mg/mL), DQ 3% diquafosol sodium (30 mg/mL)
aComparison between CN and DQ groups by Wilcoxon rank sum test
bComparison among three groups by Kruskal-Wallis test