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. 2019 Jun 3;10(6):949–953. doi: 10.1021/acsmedchemlett.9b00114

Table 3. CYP Inhibition of Compounds 18–21.

compound 1A2 IC50 (uM)a 2C9 IC50 (uM)a 2C19 IC50 (uM)a 2D6 IC50 (uM)a 3A4 IC50 (uM)a m/tb
18 >10 >10 >10 >10 8.4/6.08
19 8.95 0.94 1.15 9.61 0.35/0.95
20 >10 7.4 6.81 >10 4.57/2.6
21 >10 0.3 1.57 4.51 0.21/0.44
a

Values are expressed as the mean of three independent determinations.

b

Midazolam as substrate/testosterone as substrate.