. 2019 May 28;10(6):966–971. doi: 10.1021/acsmedchemlett.9b00123

Table 4. In Vitro Safety Profiling Data^a.

Compound	Pf 3D7 IC₅₀, nM	hERG IC₅₀, nM	hERG/3D7 Ratio	CYP 3A4 IC₅₀, nM	CYP 1A2 IC₅₀, nM	CYP 2D6 IC₅₀, nM	CYP 2C9 IC₅₀, nM	CYP 2C19 IC₅₀, nM
30a	120	5,910	49	871	>100,000	24,500	98,100	45,400
31a	91	2,572	28	159	>100,000	90,020	36,600	29,400
32a	51	2,809	55	2,500	>100,000	40,600	>100,000	49,700

Pf = P. falciparum; IC₅₀ = inhibitory concentration at 50%.

Table 4. In Vitro Safety Profiling Dataa.