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| Compound | t1/2, h | CLz, mL/min/kg | Vz, L/kg |
|---|---|---|---|
| 30a | 5.6 | 7.9 | 4.2 |
| 31a | 7.0 | 10.5 | 6.2 |
| 32a | 2.7 | 13.8 | 2.1 |
Compounds were dosed by IV cassette at 2 mg/kg/day to male KM mice (n = 6). CLz = apparent rate of clearance; Vz = apparent volume of distribution.
