Table 1.
Hemodynamics and RVH in murine CH-PH model
| Normoxia (n = 5) |
CH-PH (n = 5) |
Su/CH-PH (n = 7) |
P-value | |
|---|---|---|---|---|
| Weights | ||||
| Animal weight, g | 28.2 ± 1.2 | 25.9 ± 0.8 | 25.4 ± 0.6 | 0.09 |
| RV/BW, mg/g | 0.68 ± 0.04 | 1.11 ± 0.08*** | 1.03 ± 0.05** | 0.0004 |
| Fulton’s index, RV/LV + S | 0.229 ± 0.017 | 0.347 ± 0.018** | 0.349 ± 0.015*** | 0.0003 |
| LV + S/BW, mg/g | 3.00 ± 0.12 | 3.21 ± 0.14 | 2.97 ± 0.15 | 0.48 |
| Hemodynamics | ||||
| RVSP, mmHg | 23.2 ± 1.6 | 28.2 ± 1.2* | 28.9 ± 1.0* | 0.01 |
| RV dP/dtmax, mmHg/s | 1235 ± 178 | 1321 ± 123 | 1327 ± 70 | 0.84 |
| RV dP/dtmin, mmHg/s | − 1087 ± 135 | − 1313 ± 115 | − 1308 ± 110 | 0.36 |
| HR, bpm | 444 ± 21 | 435 ± 20 | 396 ± 12 | 0.12 |
P-value in Column 4 is for group ANOVA; Asterix reflect significance compared with Normoxia, at the given value: *P < 0.05, **P < 0.01, ***P < 0.001; RV = right ventricle; LV + S = left ventricle + septum; BW = body weight. Number of animals/group denoted in each column header