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Structure of compound 21 (green) and SAM (pink) bound to SMYD3 (cyan) (PDB ID: 5YJO). SMYD3 residues 3.5 Å away from 21 are shown in stick representation. Tyr358 and Asp332 are at 3.7 and 5.1 Å distance from 21 respectively. The electron density collected cannot detect the absolute configuration of the C6-aminomethyl group and the preferred isomer shown based on the model.
