Table 6. Effect of Compounds 4, 24−25, and 27−30 on HepG2.
HepG2
GI50 (μM) |
|||
---|---|---|---|
compd | SMYD3 IC50 (μM) | 2D | 3D |
4 | 4.78 ± 0.026 | >100 | n.d. |
24 | 0.3 ± 0.017 | >100 | n.d. |
25 | 0.17 ± 0.014 | 24.36 | 0.79 |
27 | 0.26 ± 0.026 | >100 | n.d. |
28 | 0.25 ± 0.015 | >100 | n.d. |
29 | 0.0117 ± 0.0109 | 17.69 | 1.04 |
30 | >250 | 60.77 | >10 |