Fig. 1.

Study design and patient selection. This study consisted of two steps (Step1 and 2). In Step1, 212 primary GBM cases in KNBTG enrolled as Cohort K1. From TCGA dataset, 359 cases conclusively diagnosed with primary IDH-wild-type GBM were selected as Cohort T1. In Step2, 140 patients from Cohort K1 and 152 patients from Cohort T1 were further extracted as Cohort K2 and T2, who were concurrently treated with TMZ and RT. Targeting for each cohort or step, the analyses were conducted in the Roman numerical order as follows: I, somatic genetic landscape of GBM; II, interaction among each genetic alteration; III, comparison of frequency of genetic alterations among cohorts; IV, survival difference among cohorts; V, exploration of prognostic biomarkers; VI, survival analysis between cohorts by adjustment with common prognostic biomarkers. Abbreviations: CRT, chemoradiation therapy; ET, experimental treatment; N/A, not available; pKPS, preoperative KPS; pts., patients; Rec or Sec, recurrent or secondary GBM; wt, wild type