Fig. 3.

Survival difference in Step2 across cohorts and prognostic value of triple CNA. a. Kaplan–Meier estimates of OS in Step2 for Cohort K2 (n = 140) and T2(n = 152) are shown. OS of Cohort T2 showed significantly shorter survival than that of Cohort K2 (p = 0.014) as well as in Step1, even after the adjustment of postoperative treatment background. b-c. Kaplan–Meier estimates of OS according to triple CNA are shown on each cohort: Cohort K2 (n = 140) (b) and Cohort T2 (n = 152) (c). Cases with triple CNA significantly showed a worse prognosis than that without triple CNA both in Cohort K2 (p < 0.001, Log-rank test) and Cohort T2 (p = 0.041). Median OS of cases with triple CNA were roughly 15 months that was comparable in the two cohorts. d. In the combined cohort of 292 patients (both Cohort K2 and T2), triple CNA was also a negative prognostic indicator (p < 0.001, log-rank test). Abbreviations: OS, overall survival; triple CNA, the triple overlap of copy number alterations in EGFR, PTEN and CDKN2A