Fig. 4.

Kaplan-Meier analysis of overall survival between KNBTG and TCGA after stratification by the common prognostic biomarkers. Population in Step2 (both Cohort K2 and T2) were subdivided into two subgroups either present or absent of triple CNA, MGMT methylation, elderly, or NFKBIA deletion, respectively. OS comparison between KNBTG and TCGA for each subgroup was performed with log-rank test and Kaplan–Meier plot are shown. The status of biomarkers is recognizable by solid or dotted line. Red curves indicate KNBTG, while blue ones indicate TCGA. a. The solid curves (triple CNA) are almost overlapped. There is also crossover between dotted curves (non-triple CNA). The statistical discrepancies of OS between KNBTG and TCGA resolved completely both in triple CNA subgroup (p = 0.691, Log-rank test) and non-triple CNA subgroup (p = 0.343) as shown in a table above. b-d. Even after being stratified by other prognostic factors (MGMT, generation, and NFKBIA), survival differences remained significant in at least one of the subgroups (either present or absent of these factors) as shown in each table above. Abbreviations: KNBTG, Kansai Molecular Diagnosis Network for CNS tumors; Met, methylated; OS, overall survival; TCGA, The Cancer Genome Atlas; triple CNA, the triple overlap of copy number alterations in EGFR, PTEN and CDKN2A; Unmet, unmethylated