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. 2019 Jun 17;20:503. doi: 10.1186/s12864-019-5887-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Sample clustering and heatmap for the expression of a set of 73 unique miRNAs collected from the 15 most significantly differentially expressed miRNAs from each comparison between tumor subtypes. Samples are colored by subtype according to the PAM50 classification. Red = Basal-like, purple = HER2-enriched, blue = Luminal A, and cyan = Luminal B. The miRNA expression values were standardized by row mean centering and dividing by row standard deviation in R before distance calculation and clustering