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. 2019 Jun 17;14:23. doi: 10.1186/s13020-019-0245-x

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Orally targeted HA-siCD98/CUR-NPs against UC through synergistic effects. a The fabrication process of HA-siCD98/CUR-NPs. b Scheme illustration of HA-siCD98/CUR-NPs embedded in hydrogel (chitosan/alginate) in vivo. c Accumulation of HA-functionalized NPs embedded in hydrogel in colon at four different time points after oral administration. d The concentration of fecal Lcn-2 and e H&E-stained colon sections of mice treated with different NPs for 6 days, Healthy control (1), DSS control (2), DSS + HA-siCD98-NPs (3), DSS + HA-CUR-NPs (4) and DSS + HA-siCD98/CUR-NPs (5)

(Reprinted with permission from Ref. [92]. Copyright Ivyspring International Publisher 2016)