Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 15;199(12):1517–1536. doi: 10.1164/rccm.201712-2410OC

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 by the American Thoracic Society

This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). For commercial usage and reprints, please contact Diane Gern (dgern@thoracic.org).

PMC Copyright notice

Figure 6. — Distinct populations of alveolar epithelial cells emerge during fibrosis. (A) Six clusters were identified after epithelial cells from each of eight normal and eight fibrotic lungs were combined and clustered. (B and C) Relative contributions of epithelial cells from normal and fibrotic lungs to each cluster as shown by t-distributed Stochastic Neighbor Embedding plot and by bar plots. (D) Feature plots demonstrating differential expression of selected epithelial marker genes: SFTPC (alveolar type II cells), AGER (alveolar type I cells), SCGB1A1 (club cells), FOXJ1, and RFX2 (ciliated airway epithelial cells). Also shown are genes implicated in pulmonary fibrosis (HIF1A, CHI3L1, NKX2-1, HHIP, FASN, and HES1). (E) Violin plots representing heterogeneity in expression of SERPINA1 and CHI3L1 in epithelial cells from normal and fibrotic lungs. For definition of abbreviations, see Figure 5.