FIG 11.

Disordered protein predictions for human and mouse TTP. The protein sequences for human and mouse TTP (hTTP and mTTP, respectively) were subjected to disordered protein segment predictions using DISOPRED3 (36), using default parameters. The domain structures of the two proteins are illustrated schematically at the top of the figure. NES, nuclear export signal; TZF, tandem zinc finger domain; CNBD, CNOT1 binding domain. Note that the TZF domain and CNBD especially are predicted to be ordered, with large regions of disorder predicted for large stretches of the N- and C-terminal halves of the proteins. Predicted disordered regions are indicated by blue lines, and predicted protein binding site locations by orange lines.