Figure 2.

Effects of PYY(1-36), (P³L³¹P³⁴)PYY(1-36), and PYY(1-36)(Lys¹²PAL) on insulin release from BRIN-BD11 beta-cells. BRIN BD11 cells were incubated with (A) 5.6 mM glucose, (B) 16.7 mM glucose, or (C) 16.7 mM glucose supplemented with alanine (10 mM) and the effects of PYY peptides (10^-6-10^-12 M) on insulin secretion determined. Values are mean ± SEM (n = 8). PYY indicates peptide tyrosine tyrosine.

*P < .05, **P < .01, and ***P < .001 compared with (A) 5.6 mM glucose, (B) 16.7 mM glucose, or (C) 16.7 mM glucose supplemented with alanine.