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. 2018 Nov 10;68(4):693–707. doi: 10.1136/gutjnl-2018-317570

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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βig-h3 depletion affects tumour growth in both early and advanced lesions. (A) Experimental setting. (B) Percentage of CD45⁺, CD8⁺ T cells among CD45⁺ cells and numbers/g and the percentage of EPCAM⁺ cells among CD45⁻ cells (C). (D) Experimental setting. Tumour weights. E) Experimental setting. (F) FACS analysis of the number of CD8⁺ IFNγ+ T cells and F4/80/g of tumour. (G) Representative immunohistochemistry photos for F4/80 and cleaved caspase-3 in anti-βig-h3-treated and ctrl treated KIC implanted cells in CD8⁺ T cell depleted C57Bl/6 recipients. Scale bar 100 μm. The results shown are representative of three independent experiments that included five mice per group. *P<0.05, **p< 0.01. KC, p48- Cre; Kras^G12D.