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. 2018 Nov 24;68(4):654–662. doi: 10.1136/gutjnl-2018-317178

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Perturbed intrakingdom and interkingdom ecological networks in colorectal cancer (CRC). Correlations were estimated by SParCC algorithm. Absolute correlations below 0.3 were masked to show all signals that are exclusively significant. (A) Stronger co-occurrence ecological network in CRC than control (p<0.0001, Mann-Whitney U test). New correlations among Ascomycota, Basidiomycota and Mucoromycota phyla of the fungal kingdom emerged in CRC. (B) Ecological network among differentially abundant fungi and bacterial families in CRC compared with control.