Table 1.
Association of Genetic Variation in Transporters with Plasma TMAO Concentration
| genotype | no. of patients | TMAO, μM mean (SD) | pa |
|---|---|---|---|
| OCT2 (SLC22A2) c.808G>T | |||
| G/G | 337 | 5.74 (5.68) | 0.582 |
| G/T; T/T | 70 | 5.77 (5.89) | |
| ABCB1 c.3435C>T | |||
| C/C | 76 | 5.97 (5.79) | 0.854 |
| C/T | 226 | 5.62 (5.93) | |
| T/T | 105 | 5.86 (5.20) | |
| ABCC2 c.1249G>A | |||
| G/G | 248 | 5.87 (6.03) | 0.216 |
| G/A | 138 | 5.71 (5.24) | |
| A/A | 21 | 4.54 (4.86) | |
| ABCG2 c.421C>A | |||
| C/C | 332 | 5.45 (4.80) | 0.116 |
| C/A; A/A | 74 | 7.15 (8.62) | |
a
p value calculated using Mann–Whitney U test or Kruskal–Wallis test with Dunn’s Multiple Comparison test as appropriate.