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. Author manuscript; available in PMC: 2019 Oct 10.
Published in final edited form as: Nature. 2019 Apr 10;568(7753):551–556. doi: 10.1038/s41586-019-1102-x

Fig. 1. Genome-scale functional genomic screening identifies genes synthetic lethal with MSI.

Fig. 1

a, Analyses schematic. Cell lines were grouped by feature. Dependency scores were analyzed to identify feature-specific genetic dependencies. b, Cell lines plotted by number of deletions and fraction of deletions in microsatellite (MS) regions. MSI classification by next generation sequencing (NGS) and multiplex polymerase chain reaction (PCR) are indicated. c, False discovery rate adjusted (FDR) Q values (Benjamini–Hochberg method) plotted against the mean difference of dependency scores between MSI and MSS cell lines for Projects Achilles (n = 32 MSI, 412 MSS) and DRIVE (n = 34 MSI, 327 MSS).