Table 3.
Pattern of toxicity before and after PSM
| Before PSM | After PSM | |||||
| Moderate hypofractionation | SBRT | p- value | Moderate hypofractionation | SBRT | p- value | |
| Acute rectal toxicity | ||||||
| 1 2 3 |
13 (11.9%) 14 (12.8%) 1 (0.9%) |
15 (15%) 6 (6%) 0 |
0.263 | 12 (5.6%) 9 (11.7%) 1 (1.3%) |
8 (10.4%) 5 (6.5%) 0 |
0.305 |
| 0–1 2–3 |
94 (86.2%) 15 (13.8%) |
94 (94%) 6 (6%) |
0.062 | 67 (87%) 10 (13%) |
72 (93.5%) 5 (6.5%) |
0.174 |
| Acute GI toxicity | ||||||
| 1 2 3 |
6 (5.5%) 1 (0.9%) 0 |
6 (6%) 1 (1%) 1 (1%) |
0.770 | 3 (94.8%) 1 (1.3%) 0 |
5 (6.5%) 1 (1.3%) 1 (1.3%) |
0.668 |
| 0–1 2–3 |
108 (99.1%) 1 (0.9%) |
98 (98%) 2 (2%) |
0.511 | 76 (98.7%) 1 (1.3%) |
75 (97.4%) 2 (2.6%) |
0.560 |
| Acute GU toxicity | ||||||
| 1 2 3 |
31 (28.4%) 17 (15.6%) 3 (2.8%) |
32 (32%) 31 (31%) 0 |
0.010 | 22 (28.6%) 12 (15.6%) 2 (2.6%) |
28 (36.4%) 23 (29.9%) 0 |
0.023 |
| 0–1 2–3 |
89 (81.7%) 20 (18.3%) |
69 (69%) 31 (31%) |
0.033 | 63 (81.8%) 14 (18.2%) |
54 (70.1%) 23 (29.9%) |
0.090 |
| Late rectal toxicity | ||||||
| 1 2 3 |
6 (5.5%) 5 (4.6%) 4 (3.7%) |
14 (14%) 1 (1%) 0 |
0.019 | 5 (6.5%) 4 (5.2%) 2 (2.6%) |
11 (14.3%) 1 (1.3%) 0 |
0.109 |
| 0–1 2–3 |
100 (91.7%) 9 (8.3%) |
99 (99%) 1 (1%) |
0.014 | 71 (92.2%) 6 (7.8%) |
76 (98.7%) 1 (1.3%) |
0.053 |
| Late GI toxicity | ||||||
| 1 | 1 (0.9%) | 3 (3%) | 0.272 | 1 (1.3%) | 2 (2.6%) | 0.560 |
| Late GU toxicity | ||||||
| 1 2 3 |
21 (19.3%) 10 (9.2%) 3 (2.8%) |
44 (44%) 2 (2%) 0 |
0.000 | 15 (19.5%) 6 (7.8%) 3 (3.9% |
35 (45.5%) 2 (2.6%) 0 |
0.002 |
| 0–1 2–3 |
96 (88.1%) 13 (11.9%) |
98 (98%) 2 (2%) |
0.005 | 68 (88.3%) 9 (11.7%) |
75 (97.4%) 2 (2.6%) |
0.029 |
GI, gastrointestinal; GU, genitourinary; PSM, propensity scoring matching; SBRT, stereotactic body radiation therapy.