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CTCF sites in the latent HSV-1 genome. Genomic positions of CTCF binding motifs in the HSV-1 genome are shown. There is an additional CTCF motif (CTUS1) identified by Amelio et al. not shown in this figure (19). The nucleotide position of the core CTCF binding cluster known as CTRL2 and nucleotide location of the deleted sequence used to generate the ΔCTRL2 recombinant virus are indicated. US, unique short region; RL, repeat long region; RS, repeat short region.
