FIG 2.

HSV-1 and EBV NECs and their interactions with ESCRT components. The soluble and membrane-anchored subunits of the herpesvirus NEC are shown in purple and red, respectively, with the lipid bilayer of the INM shown in gray at the bottom. ESCRT components or other relevant molecules that interact with the HSV-1 NEC (UL31p/UL34p) or the EBV NEC (BFLF2/BFRF1) are shown at the left and right of the NEC, respectively. Proteins are represented as touching an NEC subunit in cases where published data imply direct physical contact. Proteins present in a complex with the NEC subunit are connected by a solid line. Dashed lines indicate that the NEC complex influences the distribution of the protein but that no direct or indirect contact has been demonstrated. Purple spheres on EBV BFRF1 (Ub) represent polyubiquitin chains (Poly-Ub) covalently attached to lysine residues.