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. 2019 Jun 14;93(13):e00557-19. doi: 10.1128/JVI.00557-19

TABLE 1.

Summary of results of HAstV MLB1 and MLB2 propagation on selected cell linesa

Characteristic HAstV MLB1 HAstV MLB2
Origin of stool sample 1-yr-old child; Barcelona, Spain Adult allogeneic stem cell transplant recipient for acute myeloid leukemia; Geneva, Switzerland
Patient’s symptoms Gastroenteritis Meningoencephalitis; leukemia relapse
Viral titer of initial inoculum (genome copies/ml) 7.9 × 107 4.6 × 107
Acute infections
    Infected cell lines
        Caco-2 − ND
        Huh-7.5 + +
        Huh-7AI + +
        A549 + +
    Mean viral titer (genome copies/ml of SN)
        Huh-7.5 4.5 × 106 2.8 × 109
Persistent infections
    Infected cell lines
        Caco-2 − ND
        Huh-7.5 + −
        Huh-7AI + +
        A549 + +
    Mean viral titer (genome copies/ml of SN)
        Huh-7.5 5.6 × 109 −
        Huh-7AI 4.3 × 108 3.6 × 107
        A549 4.9 × 108 2.5 × 107
    Percentage of infected cells (median)
        Huh-7AI 11 8.8
        A549 4.8 8.8
a

Mean viral titers for Huh-7AI and A549 cell lines acute infections are not provided due to the few number of assays performed. ND, not done; +, successful replication; −, failure to replicate.