FIG 5.

Effects of selected hits on HSV-1 growth. HEL cells were infected with HSV-1(F) (0.01 PFU/cell) or ΔICP0 virus (0.01 PFU/cell) and either not treated or treated with compound A, C, G, or H at 10 or 100 μM, added to the cultures at the time of infection. PAA was added at 500 μg/ml at the time of infection. Infection with the ICP0 RF mutant was performed at 0.01 PFU/cell. Cells were harvested at 3, 24, and 48 h postinfection, and titration of progeny viruses was performed in Vero cells. **, P ≤ 0.01.