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. 2019 Jun 11;10:1248. doi: 10.3389/fimmu.2019.01248

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Copyright © 2019 Madkaikar, Shabrish, Kulkarni, Aluri, Dalvi, Kelkar and Gupta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Samples were analyzed by flow cytometry, for (A) the common gamma chain (γc) (Or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG on CD19 cells. (B) IL7Ra (CD 127) expression on CD3 cells. CD132 and CD127 expression was absent in patient indicative of X –SCID and AR- IL7Rα. (C) Flow cytometric evaluation of STAT5 phosphorylation following IL-2 stimulation. Patient cells fail to respond. Healthy control (Blue histogram) and SCID patient (Red histogram).