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. 2019 Jul;26(7):245–251. doi: 10.1101/lm.048447.118

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© 2019 Noble et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — Rats show no preference for the place where VNS was administered. (A) Illustration of the CPP apparatus and pairing procedure. During training, rats were blocked into each of the two opposing compartments for 20 min/day for 5 d. Four trains of VNS were delivered in the “paired” side of the apparatus and sham stimulation was delivered in the other “unpaired” side on each day, separated by 2 h. On the test trials, both compartments were open and no stimulation was given. Time spent in each compartment was measured and converted to percent of the 20-min test trial. (B) Rats did not show a preference for a place that was associated with VNS. No difference was seen in initial preference for either compartment of the CPP apparatus. After 5 d of pairing (CPP test), there was still no difference in time spent in the VNS compartment versus time spent in the sham compartment. (C) Rats show a preference for a place that was associated with a food reward. There was no difference in time spent in the two compartments at the initial preference test. However, after pairing one of the chambers with food for 5 d, rats spent significantly more time in the compartment that was previously paired with food versus the unpaired side. Vertical bars represent the mean ± SEM. Small circles indicate individual data points. (*) P < 0.05 for food-paired side in comparison to empty-paired side.