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. Author manuscript; available in PMC: 2019 Jun 18.
Published in final edited form as: Colloids Surf B Biointerfaces. 2018 Feb 24;166:37–44. doi: 10.1016/j.colsurfb.2018.02.048

Fig. 5. QNP in vivo treatment efficacy in mice bearing orthotopic GL261 tumors.

Fig. 5.

(A) Tumor growth determined by the change in tumor size (mean ± SD) from day 6 as measured by bioluminescence. (B) Survival is shown on the Kaplan-Meier plot. (C) Saline (n = 4) and BNP (n = 3) treated tumors grew exponentially and had median survival times of 21.5 and 21 days, respectively. QNP (n = 4) treatment significantly slowed tumor doubling compared to both controls, leading to a significantly prolonged survival of 27.5 days compared to BNP treatment. # designates significance (p < 0.05) compared to BNP. * designates significance (p < 0.05) compared to saline. Statistical testing on tumor doubling time was performed with a one-way ANOVA followed by Tukey post-hoc testing. Statistical testing on survival was performed by the Mantel-Cox test.