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. 2019 Jun;29(6):969–977. doi: 10.1101/gr.245399.118

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© 2019 Spektor et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Combined accessibility and methylation analysis. (A) DNA methylation at mATAC-seq peaks from HCT116 and DKO cells form five distinct clusters by DNA methylation. (B) mRNA expression in log₂ CPM at identified clusters. Features in Clusters 1, 4, and 5 are depicted according to accessibility (C), DNA methylation (D), activating histone modifications (E), silencing histone modifications (F), and CTCF (G). Motifs enriched in Cluster 1 (H) and Cluster 4 (I), compared to Cluster 5. Q-values are for Wilcoxon tests with Benjamini–Hochberg correction.