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. 2019 Jun;29(6):907–919. doi: 10.1101/gr.241372.118

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© 2019 Argilaguet et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — Chronic-darkturquoise-specific module reveals an important role of XCL1 in chronic infection. (A) Normalized expression kinetics of genes from the chronic-darkturquoise module and their corresponding kinetics in acute infection. (B) Xcl1 expression kinetics obtained from RNA-seq analysis. (C) Percentages of XCL1-producing NK and CD8⁺ T cells at day 9 PI. Data shown are the mean ± SEM from n = 11 to 13 mice representative of three independent experiments (significance determined using one-way ANOVA). (D,E) MFI of XCL1 in DbGP33-41⁺ CD8⁺ T cells (D, right) and percentages of XCL1-producing DbGP33-41⁺ CD8⁺ T cells (D, left) and CXCR5- or CXCR5⁺ DbGP33-41⁺ CD44⁺ CD8⁺ T cells (E) at day 9 PI. Data shown are the mean ± SEM from n = 11 to 13 mice (significance determined using unpaired two-tailed t-test). (ns) not significant; (**) P ≤ 0.01; (***) P ≤ 0.001; (****) P ≤ 0.0001.