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. Author manuscript; available in PMC: 2020 Mar 13.
Published in final edited form as: Cell Host Microbe. 2019 Mar 13;25(3):432–443.e6. doi: 10.1016/j.chom.2019.02.008

Figure 4. NanoString reveals induction of hypha-associated and pH-responsive genes in commensally propagated C. albicans.

Figure 4.

A) Schematic of NanoString experiment. Animals were colonized with wild type (ySN425) for 1, 4 and 10 days. RNA recovered from stomachs, ceca, and large intestines was analyzed with 182 NanoString primer sets. B) Heatmap of expressed hypha-associated genes. Upregulation relative to the inoculum is indicated in yellow, downregulation in blue. Final two columns indicate the −log10(adjusted p-value) of expression differences between the gut vs. laboratory conditions (Gut/YPD) or the stomach vs. distal compartments (Stomach/Distal). Significance was determined using a linear fit model. C) Heatmap of expressed pH-associated genes. The full NanoString dataset appears in Table S2.