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. 2019 Jan 25;90(6):642–651. doi: 10.1136/jnnp-2018-320050

Figure 1.

Figure 1

Pathophysiological mechanisms of fatigue discussed in this article. White and grey boxes represent classes of mechanisms and specific mechanisms, respectively; directed arrows and circle-ended arrows represent direct and mediating effects, respectively. Due to space limitations, only one mechanism per arrow is shown; see main text for other mechanisms. CNS, central nervous system; DA, dopamine; GM, grey matter; NAWM, normally appearing white matter; WM, white matter.