Table 3.

Univariate and multivariate cox regression analyses for overall survival in patients with nasopharyngeal carcinoma in the validation cohort

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	P values	HR (95% CI)	P values
Sex
Female versus male	0.53 (0.29 to 1.00)	0.049*	0.76 (0.40 to 1.45)	0.408†
Age
≥50 versus <50	1.77 (1.05 to 2.99)	0.034*	1.96 (0.95 to 4.52)	0.056†
BMI
>25 versus ≤25	0.72 (0.39 to 1.33)	0.294
T stage		0.004*		0.002*†
T1	Ref.		Ref.
T2	4.93 (1.15 to 21.08)	0.032*	5.03 (1.17 to 21.76)	0.030*
T3	5.41 (1.28 to 22.91)	0.022*	5.37 (1.26 to 22.91)	0.023*
T4	10.24 (2.39 to 43.84)	<0.001*	11.48 (2.65 to 49.68)	0.001*
N stage		0.010*		0.010*†
N0	Ref.		Ref.
N1	2.90 (0.97 to 8.62)	0.056	3.08 (1.03 to 9.23)	0.044*
N2	3.28 (1.16 to 9.31)	0.026*	4.20 (1.46 to 12.07)	0.008*
N3	6.38 (2.06 to 19.71)	0.001*	6.64 (2.11 to 20.91)	0.001*
Chemotherapy
Yes versus no	1.05 (0.60 to 1.82)	0.868
IMRT
Yes versus no	0.92 (0.56 to 1.53)	0.756
SIRI
>0.84 versus ≤0.84	3.10 (1.69 to 5.68)	<0.001*	2.91 (1.56 to 5.41)	0.001*†
NLR
>1.85 versus ≤1.85	2.82 (1.44 to 5.52)	0.003*	2.99 (1.51 to 5.95)	0.002*‡
PLR
>112 versus ≤112	1.57 (1.03 to 2.70)	0.042*	1.74 (1.01 to 3.03)	0.048*§
MLR
>0.29 versus ≤0.29	1.77 (1.08 to 2.90)	0.024*	1.54 (0.93 to 2.54)	0.093¶

*represents a statistically significant difference.

†The variables (sex, age, T stage, N stage and SIRI) were tested in a multivariate analysis.

‡The variables (sex, age, T stage, N stage and NLR) were tested in a multivariate analysis.

§The variables (sex, age, T stage, N stage and PLR) were tested in a multivariate analysis.

¶The variables (sex, age, T stage, N stage and MLR) were tested in a multivariate analysis.

BMI, body mass index;  IMRT, intensity-modulated radiotherapy; MLR, monocyte lymphocyte ratio; NLR, neutrophil lymphocyte ratio; PLR, platelet lymphocyte ratio; Ref, reference;  SIRI, Systemic Inflammation Response Index.