Table 3.
Linear Regression Analyses Between Neutrophil Count and the Whole Volume of Some Relevant Brain Regions of First-Episode Psychosis Patients That Were Identified in Previous Voxel-Based Morphometry Analyses
| Brain Area | Neutrophil Count | Age | Total Brain Volume | R 2 | F Test | P Value |
|---|---|---|---|---|---|---|
| Gray matter | ||||||
| Entorhinal area | −0.194*** (FDR) | −0.044 | 0.641**** | .512 | 46.585 | <.001 |
| Inferior temporal gyrus | −0.127*** (FDR) | −0.149**** | 0.812**** | .792 | 168.527 | <.001 |
| Temporal pole | −0.168*** (FDR) | −0.134** | 0.688**** | .609 | 68.966 | <.001 |
| Precentral gyrus | −0.157*** (FDR) | −0.171*** | 0.705**** | .652 | 82.891 | <.001 |
| Thalamus | −0.211*** (FDR) | −0.111 | 0.449**** | .324 | 21.244 | <.001 |
| Middle temporal gyrus | −0.117*** (FDR) | −0.206**** | 0.789**** | .787 | 163.769 | <.001 |
| Superior frontal gyrus | −0.114*** (FDR) | −0.307**** | 0.731**** | .774 | 151.829 | <.001 |
| Left Heschl’s gyrus | −0.170** (FDR) | −0.027 | 0.610**** | .450 | 36.279 | <.001 |
| Occipital fusiform gyrus | −0.149** (FDR) | −0.120* | 0.678**** | .573 | 59.512 | <.001 |
| Anterior insula | −0.133** (FDR) | −0.113* | 0.710**** | .608 | 68.805 | <.001 |
| Lingual gyrus | −0.135* (FDR) | −0.149** | 0.658**** | .553 | 54.825 | <.001 |
| Cerebellum | −0.132* (FDR) | −0.211**** | 0.616**** | .534 | 50.720 | <.001 |
| Frontal operculum | −0.130* (FDR) | −0.175*** | 0.631**** | .529 | 49.729 | <.001 |
| Postcentral gyrus | −0.114 † | −0.235**** | 0.644**** | .580 | 61.210 | <.001 |
| Superior temporal gyrus | −0.061 | −0.262**** | 0.745**** | .727 | 117.766 | <.001 |
| Posterior cingulate cortex | −0.038 | −0.220**** | 0.732**** | .662 | 86.904 | <.001 |
| Cerebrospinal fluid | ||||||
| Lateral ventricles | 0.196*** (FDR) | −0.009 | 0.543**** | .293 | 18.379 | <.001 |
| Third ventricle | 0.152 + | 0.044 | 0.448**** | .194 | 10.680 | <.001 |
| Fourth ventricle | 0.129 | −0.053 | 0.460**** | .215 | 12.114 | <.001 |
Note: Along with neutrophil count, age and total brain volume were included as additional predictors to control for their effects. See figure 2 and supplementary table 1 for further information. (FDR) = significant after correcting for multiple comparisons with the Benjamini–Hochberg procedure. Statistically significant associations are marked in bold.
+ P = .062; †P = .051; *P < .05; **P < .025; ***P ≤ .01; ****P < .001.