Table 1.
Results of fMRI Activation Analysis
Contrast | Anatomical region | Hemisphere | Voxel per cluster | X | Y | Z | F/t value |
---|---|---|---|---|---|---|---|
Conjunction | |||||||
Cluster 1 | Inferior parietal lobule | Right | 30 278 | 32 | −50 | 44 | 9.24a,b |
Supramarginal gyrus | Right | 50 | −44 | 42 | 9.06a,b | ||
Superior parietal lobule | Right | 26 | −66 | 54 | 8.72a,b | ||
Inferior parietal lobule | Right | 42 | −44 | 46 | 8.68a,b | ||
Cerebellum | Left | −8 | −76 | −28 | 7.91a,b | ||
Superior parietal lobule | Left | −24 | −66 | 52 | 7.41a,b | ||
Inferior occipital gyrus | Left | −40 | −82 | −8 | 7.40a,b | ||
Cluster 2 | Precentral gyrus | Right | 22 085 | 46 | 6 | 32 | 9.55a,b |
Insula | Right | 32 | 22 | −2 | 8.84a,b | ||
Inferior frontal gyrus | Right | 46 | 36 | 26 | 8.18a,b | ||
Posterior-medial frontal gyrus | Right | 6 | 24 | 48 | 8.07a,b | ||
Middle frontal gyrus | Right | 44 | 42 | 20 | 7.59a,b | ||
Insula | Left | −34 | 18 | −2 | 6.67a,b | ||
Superior frontal gyrus | Right | 26 | 16 | 62 | 6.18a,b | ||
Cluster 3 | Precentral gyrus | Left | 3183 | −44 | 4 | 30 | 7.84a,b |
Inferior frontal gyrus | Left | −44 | 30 | 28 | 5.59a,b | ||
Middle frontal gyrus | Left | −44 | 22 | 42 | 4.10a,b | ||
Superior frontal gyrus | Left | −22 | 16 | 62 | 2.76a,b | ||
Cluster 4 | Middle frontal gyrus | Left | 871 | −38 | 46 | 2 | 4.48a,b |
Cluster 5 | MCC | Right | 394 | 6 | −28 | 30 | 5.09a,b |
Interaction effect of group × task | |||||||
Cluster 1 | Posterior-medial frontal gyrus | Left | 457 | −4 | −8 | 54 | 15.29a,b |
Cluster 2 | Temporoparietal junction | Right | 270 | 44 | −54 | 28 | 19.51a,b |
Cluster 3 | Superior frontal gyrus | Right | 269 | 24 | 44 | 44 | 14.76a,b |
Right superior medial gyrus | Right | 14 | 48 | 46 | 12.79a,b | ||
Cluster 4 | Precentral gyrus | Left | 171 | −26 | −18 | 74 | 12.80a |
Cluster 5 | Superior frontal gyrus | Right | 130 | 20 | 64 | 16 | 16.28a |
Cluster 6 | Cerebellum | Left | 69 | −22 | −80 | −34 | 11.14a |
Cluster 7 | Cuneus | Right | 67 | 22 | −84 | 46 | 11.43a |
Post hoc t contrast | |||||||
HC(TASK > CONT) > SZ(TASK > CONT) | |||||||
Cluster 1 | Superior frontal gyrus | Right | 475 | 24 | 44 | 44 | 3.84a,b |
Superior medial gyrus | Right | 14 | 48 | 46 | 3.58a,b | ||
Cluster 2 | Temporoparietal junction | Right | 395 | 44 | −54 | 28 | 4.42a,b |
Cluster 3 | Superior frontal gyrus | Right | 214 | 20 | 64 | 16 | 4.04a |
Cluster 4 | Cuneus | Right | 133 | 22 | −84 | 46 | 3.38a |
Cluster 5 | Cerebellum | Left | 133 | −22 | −80 | −34 | 3.34a |
SZ(TASK > CONT) > HC(TASK > CONT) | |||||||
Cluster 1 | Posterior-medial frontal gyrus | Left | 667 | −4 | −8 | 54 | 3.91a,b |
Cluster 2 | Precentral gyrus | Left | 297 | −26 | −18 | 74 | 3.58a |
Note: All reported regions were corrected for multiple comparisons on a cluster threshold of P < .05.
aVoxel threshold: P = .005, k = 67 voxel.
bVoxel threshold: P = .001, k = 47 voxel.
Coordinates are reported in MNI space.
fMRI = functional magnetic resonance imaging.