Table 2.
Regions of significant differences in quantitative diffusion imaging parameters between ALS and control (CTL) groups
| Contiguous anatomical regions within cluster | MNI coordinate (x, y, z) | t-Value | K (size) | Pclusterlevel FWE-corr |
| NDI (ALS<CTL) | ||||
| Right cerebral cortex, precentral gyrus | 11, −25, 60 | 5.85 | 15 344 | <0.001 |
| Right cerebral WM, corticospinal tract | 22, −22, 46 | 5.69 | ||
| Right posterior limb of the internal capsule | 23, −12, 7 | 5.21 | ||
| Left posterior limb of the internal capsule | −24, −11, 12 | 6.23 | 14 005 | <0.001 |
| Left cerebral WM, corticospinal tract | −13, −28, 58 | 5.32 | ||
| Left superior corona radiata | −20, −20, 41 | 4.91 | ||
| ODI (ALS<CTL) | ||||
| Right precentral gyrus | 32, 5, 27 | 3.89 | 1847 | 0.014 |
| Right precentral gyrus | 25, −1, 44 | 3.60 | ||
| Right anterior internal capsule | 21, 9, 21 | 3.59 | ||
| ISO (ALS>CTL) | ||||
| Right caudate, lateral ventricle | 11, 18, 4 | 3.45 | 2960 | 0.006 |
| Right anterior corona radiata | 20, 23, 19 | 3.39 | ||
| Right genu of corpus callosum | 8, 25, 8 | 3.30 | ||
| FA (ALS<CTL) | ||||
| Right precentral gyrus | 15, −23, 66 | 5.10 | 4097 | <0.001 |
| Right cerebral corticospinal tract | 26, −23, 49 | 4.36 | ||
| Right superior corona radiata | 18, −21, 42 | 4.19 | ||
| Left cerebral WM, corticospinal tract | −15, −23, 67 | 5.25 | 2877 | 0.002 |
| Left cerebral cortex, precentral gyrus | −21, −18, 70 −18, −15, 59 |
4.32 4.08 |
||
| Right pons, corticospinal tract | 7, −26, −37 | 5.11 | 2309 | 0.006 |
| Right brainstem, corticospinal tract | 3, −34, −47 | 5.10 | ||
| Left pons, corticospinal tract | −7, −23, −36 | 4.69 | ||
| MD (ALS>CTL) | ||||
| Left superior corona radiata | −24, −19, 35 | 4.78 | 3315 | 0.048 |
| Left posterior limb of the internal capsule | −18, −15, 3 −20, −17, 14 |
3.55 3.43 |
||
The table shows the anatomical regions where significant changes were demonstrated on whole brain analysis in neurite density index (NDI), orientation dispersion index (ODI), isotropic compartment (ISO), fractional anisotropy (FA), and mean diffusivity (MD). A statistical significance threshold of p<0.05 family-wise error (FWE) correction at the cluster level (Pcluster) was used, after clusters were formed with an uncorrected p<0.001. Montreal Neurological Institute (MNI) coordinates were used to define the anatomical location of each cluster of voxels within the MRI volume. The MNI coordinates refer to the peak t-value. Local maxima that are more than 8 mm apart are shown for each cluster. K indicates the size of the cluster in voxels.
ALS, amyotrophic lateral sclerosis; WM, white matter.