FIG 4.

Loci and genetic environments of CTX-M and CMY-2 genes. (A to D) The loci of CTX-M/CMY-2 genes in JEONG9598 (A), JEONG9566 (B), and JEONG5446 (C). The contigs (blue, green, red, and purple nodes) of the isolates were assigned to either the bacterial chromosome (gray background) or a plasmid (white background) based on their homology to reference genomes/plasmids (orange nodes) using PLACNETw and manual pruning. The sizes of the blue, green, red, or purple nodes are in proportion to the lengths of the contigs, while the size of the orange nodes (reference genomes/plasmids) is the same. Purple nodes represent contigs containing a CTX-M or CMY-2 gene. (D) Comparison of genetic environments surrounding the CTX-M or CMY-2 gene in representative isolates. The genes surrounding each CTX-M or CMY-2 (red arrows) gene contain insertion sequences (yellow arrows) and other genes as indicated (green arrows). Similarities (gray shading) of the genetic environments between isolates were analyzed using BLASTn.