FIG 4.

Relationship between the existence of nonsynonymous mutations or SNPs in target genes and MICs to each antimicrobial agent. The box-and-whisker plot indicates the maximum, upper quartile, median, lower quartile, and minimum MIC value. As for fluoroquinolones, gyrA (Ser83) + parC (Ser80) refers to isolates in which the coexistence of amino acid substitutions at Ser83 in gyrA and Ser80 in parC was confirmed, and gyrA + parC (others) refers to isolates in which combinations of other amino acid substitutions were confirmed. Significant differences were evaluated by the Mann-Whitney U test. ****, P < 0.0001; ***, P < 0.001; **, P < 0.01; *, P < 0.05.