. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: Curr Opin HIV AIDS. 2019 Jul;14(4):253–264. doi: 10.1097/COH.0000000000000558

Table 1:

Examples of studies in which ML has been employed to derive insights into humoral immunity.

Species	Observations	Reference
Correlates of Immunity
Human	Relationships between humoral response features and established correlates of reduced risk.	(24, 64)
NHP	Identification of correlates of vaccine efficacy.	(39, 40, 44, 65–71)
Group Differences
Human	Differences between subjects receiving different vaccines.	(24, 64)
	Differences in humoral response among controllers and progressors.	(50, 72)
	Differences in humoral responses among subjects who do versus do not develop broadly neutralizing antibodies.	(42, 73, 74)
	Differences in humoral response observed among subjects differing by genotype.	(43)
NHP	Differences in humoral response among subjects immunized with different vaccines.	(39, 40, 70)
	Differences in humoral response among subjects immunized with different adjuvants.	(44, 48, 65)
	immune responses in male and female macaques in response to vaccination	(75)
	Differences in humoral response among subjects immunized by different routes.	(39)
Antibody Activities
Human	Biophysical features associated with diverse effector functions among vaccine recipients.	(24, 45, 49, 76)
Human	Biophysical features associated with diverse effector functions among HIV infected subjects.	(43, 44, 46, 50, 77)
NHP	Biophysical antibody features associated with diverse effector functions among vaccinated subjects.	(39, 75)