Table 3.

Median mRNA levels (quantitative relative expression) of skeletal muscle transcripts affected by aging and/or exercise as measured by quantitative RT RT-PCR

	Young, n = 15		Elderly, n = 16
Transcript, Accession No.	Pre Post		Pre Post		Sig
α-Cardiac actin (ACTC1), NM_005159	0.52	3.38	0.47	1.35	C
Atrogin-1 or F-box protein 32 (MAFbx), NM 058229	20.85	14.66	12.22	11.03	A
Ciliary neurotrophic factor (CNTF) NM 000614	36.00	44.95	20.52	25.15	A, B
Connective tissue growth factor (CTGF), NM_001901	4.46	3.66	3.27	3.19
Early growth response protein-1 (EGR1), NM 001964	2.90	2.58	2.07	2.50
Fibroblast growth factor-6 (FGF6), NM_020996	6.52	7.95	4.11	6.99
Fibronectin (FN1), X02761	5.95	10.22	3.60	6.43	A
Growth and differentiation factor 8 or myostatin (GDF8), NM_005259	49.33	23.61	25.79	14.80	A, C
Insulin-like growth factor binding protein-5 (IGFBP5), NM_000599	90.66	64.95	39.17	37.63	A, B
Insulin-like growth factor-1 (IGF1), NM_000618 ‘	43.67	46.50	19.29	28.77	A, B
Matrix metallopeptidase-2 (MMP2), NM_004530	8.41	13.58	5.21	7.95	A, B
Osteosarcoma viral oncogene homolog (c-fos), AY212879	0.46	0.70	0.24	0.16	A
TIMP metallopeptidase inhibitor-1 (TIMP1), X03124	12.54	24.74	12.85	15.72	C
Vascular endothelial growth factor-A (VEGFA), M32977	8.70	8.54	4.92	5.79	A
Vascular endothelial growth factor-D (VEGFD), NM_004469	18.07	15.35	7.25	7.38	A

Significance (Sig) was accepted at P ≤ 0.05. Significance is noted by A, B, or C for the following comparisons: A = young vs. elderly pre-exercise, B = young vs. elderly post-exercise, C = pre- vs. post-exercise in young, and there were no significant differences found for pre- vs. post-exercise in elderly